Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Roy-Bz 是第一个小分子 PKCδ 选择性激活剂，EC50 为 58.5 nM，与 PKCδ-C1 结构域结合。

PKC-theta 抑制剂是一种选择性 PKC-θ 抑制剂 (IC50:12 nM)。